This Handbook presents recent trends and new developments in Data Envelopment Analysis (DEA) research within the realms of business, finance, and sustainability. Divided into three distinct parts, it encompasses 19 chapters that offer insightful studies conducted in diverse national environments and organizational settings.Part I focuses on DEA applications in business, including healthcare, supply chain management, and governmental organizations. Part II delves into the application of DEA in banking and finance, providing valuable insights into the efficiency and performance of financial institutions. Part III explores DEA's diverse applications in sustainability, addressing topics such as sustainability indicators, resource mobilization, food production, and farming. In essence, this Handbook stands as an invaluable reference work for stakeholders seeking to optimize organizational efficiency and performance across a variety of sectors.