Transnational drug crime in the ASEAN region involves cross-border illicit drug trafficking, posing significant challenges to regional security and stability. The Golden Triangle, which spans Laos, Myanmar, and Thailand, is one of the main regions where transnational drug trafficking is a significant concern. The region has seen a huge increase in transnational crime and synthetic drugs, with estimates suggesting that hundreds of tons are trafficked overseas. Transnational drug crime significantly affects Indonesia's national security in several ways. Increasingly easy sales via social media and postal delivery, which is characterized by significant seizures, particularly of cocaine, by 2022. Trafficking in synthetic drugs, particularly methamphetamine, is growing rapidly in Indonesia. Indonesia acts as a transit point with major domestic producers receiving support from the government which amplifies the complexity of the market. Overall, drug consumption has increased significantly in the country, particularly of synthetic drugs. Analyzing this effort using the framework of drug trafficking and national security can shed a comprehensive light on this issue. This research will focus on 2021-2023 with a qualitative research method using secondary data collected through literature review. Keywords: Transnational Organized Crime, Crime Threats Transnational Narcotics Crime Threat, Indonesian National Security