Red star begonia is an ornamental plant from the Angiospermae group which has distinctive characteristics in its parts so it is in great demand and has been widely traded so its availability is necessary. Propagation of red star begonia plants can be done vegetatively, namely by using leaves. However, propagation by leaves has weaknesses, namely that the cutting material dries out easily, rots, makes it difficult to grow roots and even dies. To overcome this, it is necessary to add ZPT (Growth Regulatory Substance, one of which is Rootone F. This research was conducted to determine the best combination of cutting material and concentration of Rootone F in the growth of leaf cuttings of red star begonia plants. The research used a factorial Completely Randomized Design (CRD). 2 levels and 4 levels with 3 repetitions and 3 samples, namely whole leaves and sliced leaves, while the second factor is soaking Rootone F with concentrations of 250 ppm, 300 ppm, 350 ppm, 400 ppm and a comparison treatment of 0.4 g/ cuttings were given topically.The research results showed that the combination of cutting material treatment with soaking in various concentrations of Rootone F, there was an interaction between the combination of whole leaf treatment and a concentration of Rootone F of 400 ppm showed the best results on the observation parameters. There was an interaction on the observation parameters, percentage of rooted cuttings, percentage of cuttings. sprouted, and the percentage of live cuttings, stem length aged 63, 77 and 91 HST, number of leaves, root length and number of primary roots. The treatment of sliced leaf cutting material had a real influence on the observation parameters when the leaves fully opened. The Rootone F concentration treatment of 350 ppm had a real influence on the observation parameters of the initial time of shoot emergence, the time each shoot appeared. Keywords: Cutting material, Rootone F, Red star Begonia, Growth of leaf cuttings.