The problem of poverty levels in Tuban Regency until 2022 is still ranked fifth in East Java. The level of poverty can certainly be an obstacle to development and there are several factors that cause the high level of poverty in Tuban Regency, namely population, economic growth, education level and unemployment level. This research aims to determine the influence of the independent variable on the dependent variable in Tuban Regency in 2002-2022. This research was conducted based on data from BPS (Central Statistics Agency) Tuban Regency. The approach taken by researchers is to use quantitative methods using multiple linear regression analysis. With the results, population has a significant negative effect on poverty levels, economic growth has no effect on poverty levels, education level has a significant positive effect on poverty levels, and poverty levels have no effect on poverty levels in Tuban Regency.